Join Us
Help Our Cause
We are actively pursuing research on non-invasive, video-based methods for seizure detection, and we need your help to advance technology to help individuals with brain injury and to support training the next generation of researchers!
Research Interest
Mechanisms of Brain injury and Repair: Cerebrovascular Remodeling, Neurogenesis and Neuroinflammation
- Our laboratory investigates Eph receptor biology and function in the context of brain injury. Eph receptors are developmentally important molecules critical for axon growth & guidance, which we discovered play a vital role in regulating injury-induced vascular remodeling, neuroinflammation, and blood-brain barrier integrity. This work has been highlighted in the Journal of Clinical Investigation and PNAS. We interrogate Eph signaling using conditional gene-targeted approaches in murine models of stroke, traumatic brain injury, and post-traumatic epilepsy. A variety of cellular, molecular, and advanced imaging tools, including single-cell RNAseq, are integrated into studies focused on understanding the key mechanistic pathways underlying neurovascular and neuroimmune health.
- Toward our long-term translational goal, we have begun testing several novel peptides for their therapeutic potential in treating brain injury. We are simultaneously developing cell-based and cell-targeted delivery methods aimed at limiting the extent of tissue damage, promoting vascular integrity, and retooling the neuroinflammatory milieu.